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A mathematical model was developed to explain the physicochemical kinetics of 212Pb-labeled pharmaceuticals and its own radioactive daughters. Materials and Methods A bolus of 212Pb-labeled pharmaceuticals injected in a developed compartmental design was simulated. The efforts of chelated and free radionuclides to the total released energy had been examined for various dissociation fractions of 212Bi for various chelators, for example, 36% for DOTA. The compartmental design was applied to spell