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Health Issues That Affect German Shepherd Life Expectancy German Shepherds peak between the ages of 2 and 6. They are at their best in terms of physical fitness and mental sharpness. Their size puts them at a greater risk of developing cancer, muscular and skeletal issues, as well as other health conditions that may affect their lifespan. Working line German Shepherds usually have more active lives than their show line counterparts. They require a nutrient-rich diet to support their activity levels and exercise demands. Cushing's Disease German Shep