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On the contrary, calcium hydroxide showed the worst clinical performance. Although medically effective, formocreosol should always be changed by other materials, due to its potential cytotoxicity and carcinogenicity. Conclusion MTA seemed to be the gold standard product when you look at the pulpotomy of major teeth. Encouraging results were additionally given by calcium silicate-based cements. Further randomized medical tests (RCTs) with adequate test sizes and lengthy follow-ups ought to support