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How Does ADHD Medication Work? Medicines reduce ADHD symptoms by increasing the levels of chemicals noradrenaline and dopamine that transmit messages between brain cells. The most frequently prescribed stimulants are methylphenidate, Glycine and atomoxetine. Finding the right medication and dose can require a lot trial and trial and. Your doctor's communication with you should be open and honest. Stimulants The stimulant drugs prescribed to treat ADHD increase levels of dopamine a