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Joint contact forces and contact places were very responsive to ACL and PCL pre-strains, while those changed less cartilage stresses, fibril strains, and fluid pressures. The provided workflow could possibly be used in a wide range of applications associated with the aetiology of cartilage degeneration, optimization of rehab exercises, and simulation of leg surgeries.Allosteric modulation is involved with a plethora of diverse necessary protein features, that are fundamental f