https://www.selleckchem.com/pr....oducts/a-d-glucose-a
Either elevated expression of or partial loss of SIRT1 inhibited cell proliferation and induced cell apoptosis. Accumulation of BAX and cleaved CASPASE-8/9/3, inhibition of PGC-1α/NRF2 pathway, increase oxidative stress and reduction of BCL-2 as well as uncleaved PARP were found in the presence of or the absence of . Overexpression of could reduce anti-proliferative and pro-apoptotic effects of . Overall, this study concluded that -dependent inhibition displays anti-proliferative and proapoptotic roles in PC cells via PGC-
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