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Right here, utilizing a few personal cellular outlines, immunofluorescence and structured illumination microscopy methods, and ubiquitination assays, we reveal that the E3 ubiquitin ligase F-box and WD repeat domain containing 7 (FBXW7), a subunit of this SCF ubiquitin ligase, down-regulates spindle installation 6 homolog (HsSAS-6), a key protein required for pro-centriole cartwheel installation, and thereby regulates centriole replication. We found that FBXW7 abrogation stabiliz
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