https://www.selleckchem.com/pr....oducts/as2863619.htm
Despite a recent expansion in the recognition of coproporphyrin's (CP's) potential utility as an endogenous biomarker of OATP1B activity, there have been few detailed studies of C's pharmacokinetic behavior and an overall poor understanding of its pharmacokinetic fate from tissues and excretion. Here, we describe the pharmacokinetics of deuterium-labeled coproporphyrin I (CPI-d8) in cynomolgus monkeys following oral and intravenous administration. CPI-d8 has a half-life and bioavailability of 7.6 h and 3.2, respectively. Cynomolg
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