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The results were evaluated using the chi-square test. RESULTS Compared with the other groups, a statistically significant difference was found in edema, inflammation, and vascular proliferation in the nitroglycerin group. Significantly more intense staining for CD 34 was found in the nitroglycerin group compared with the other groups. Immunohistochemical staining for D 2-40 was also found statistically significant in the nitroglycerin group (p less then 0.05). CONCLUSION A topical containing 2% nitroglycerin increases vascular proliferati