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The liver plays a central role in the postpartum (PP) energy metabolism of the transition dairy cow; however, studies describing the liver metabolome during this period were lacking. The aim of the presented study was therefore to compare the alterations in the liver and blood metabolome of transition dairy cows. For this purpose, an on-farm trial with 80 German Holstein cows (mean lactation number 3.9; range 2-9) was performed, with thorough documentation of clinical traits and clinical chemistry, as well as production data. Liver biopsi
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