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Good staining of testicular germ cells for PLAP and c-Kit beyond infancy is linked to the presence of GCNIS (Germ Cell Neoplasia In Situ). We recently reported our conclusions of positive staining of typical, infantile germ cells for PLAP, and c-Kit up to 2years of age, contrary to earlier scientific studies. The present study is designed to elucidate whether otherwise normal testes of males undergoing puberty present PLAP, c-Kit, Oct3/4, or D2-40. The aim of this organized review was to c