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These results suggest that HNF1β may ameliorate cisplatin nephrotoxicity in vitro and in vivo, probably through regulating NF-κB signalling pathway.Developmental researchers commonly utilize multilevel models (MLMs) to describe and predict individual differences in change over time. In such growth model applications, researchers have been widely encouraged to supplement reporting of statistical significance with measures of effect size, such as R-squareds (R2 ) that convey variance explained by terms in the model. An integrative framework