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Research on both the direct anti-cancer activity and the drug delivery capabilities of ELPs is another area likely to result in novel therapeutic agents in the near future.Phase-amplitude coupling (PAC) is proposed to play an essential role in coordinating the processing of information on local and global scales. In recent years, the methods able to reveal trustworthy PAC has gained considerable interest. However, the intrinsic features of some signals can lead to the identification of spurious or waveform-dependent coupling. This promp