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ADHD Stimulant Medication Stimulants are used to treat conditions such as hyperactivity and inattention. They usually take effect in 30 to 60 minutes. They are the first line of treatment for people with ADHD. Stimulants alter the activity of key neurotransmitters dopamine and noradrenaline in the tiny gaps between neurons, also known as synapses. They also improve the communication between neurons. Methamphetamine Methamphetamine (also known as meth, crystal, ice or s