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61 (1.03-2.51; p = 0.03), while with the 25 mg dose, it was 2.23 (1.55-3.18; p 0.001). However, 25 mg OCA led to significant adverse events and discontinuation of the drug [2.8 (1.42-3.02); p 0.001)] compared with 10 mg OCA [0.95 (0.6-1.5); p = 0.84] in NASH patients. In PBC patients, the response to 5 mg OCA was better than with the higher doses [5 mg 7.66 (3.12-18.81; p 0.001), 10 mg 5.18 (2-13.41; p = 0.001), 25 mg 2.36 (0.94-5.93; p = 0.06), 50 mg 4.08 (1.05-15.78; p = 0.04)]. The risk of pruritus was lowest with 5 m