https://www.selleckchem.com/pr....oducts/l-histidine-m
This article proposes four new principles for logical biomarker cut-point selection methods to adhere to subgroup sensibility, sensitivity, specificity, and target monotonicity. At every cut-point value, our method gives confidence intervals not only for the efficacy at that cut-point value, but also efficacies in the marker-positive and marker-negative subgroups defined by that cut-point. These confidence intervals are given simultaneously for all possible cut-point values. Using Alzheimer's disease (A
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