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12 per 100 when the risk score cutoff (0.003 was selected for a comparable size of high-risk individuals (n = 15,881) than those meeting the overlapping opioid/benzodiazepine prescriptions (n = 17,440; 33.2% of total deaths; 4.64 deaths per 100 and high MME (n = 14,675; 24.6% of total deaths; 4.09 deaths per 100 thresholds. Conclusions The predictive model identified more individuals at risk of fatal opioid overdose as compared with PDMP thresholds commonly used for unsolicited reporting. PDMP programs could improve their targetin