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The current article discusses the need for a balanced diet, the traits to be considered before designing a diet, and certain problems in the existing synthetic medium. Therefore, based on the control food composition, the validity of lifespan extension conferred by these nutrient restricted diets need to be accounted for.Despite numerous experimental observations regarding heart failure with preserved ejection fraction (HFpEF), which is characterized mainly by left ventricular hypertrophy and a left ventricular ejection fraction over 5