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As there is no current evidence from any randomized control trails (RCTs) to recommend any specific treatment for suspected or confirmed patients with COVID-19 with acute necrotizing encephalitis. Our case highlights the importance of identifying encephalitis as a presenting sign of COVID-19 based on NCCT findings with normal cerebrospinal fluid (CSF) and normal chest X-ray (CXR) findings. Kumar N, Kumar S, Kumar A, Pati BK, Kumar A, Singh C, Acute Necrotizing Encephalitis as a Probable Association of COVID-19. Indian J Crit Care Med 2