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52), and is also an effective contrast agent at 0.5 T ( / = 2.49), while 4-nm SPIO@PEG5k is a - dual-mode contrast agent at 3.0 T ( / = 5.24), and is a useful contrast agent at 0.5 T ( / = 1.74) and 1.5 T ( / = 2.85). MRI studies in vivo at 3.0 T further confirm that 4-nm SPIO@PEG5k displays excellent - dual-mode contrast enhancement, whereas 8-nm SPIO@PEG5k only displays contrast enhancement. PEGylated SPIOs with different nanocrystal sizes and PEG coating can be used as , , or - dual-mode contrast agents to meet the clinical demands o