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Granulomatous response and lichenoid response were seen in five and three biopsies, respectively. Legalization is needed for this practice to prevent tattoo reactions. Histopathological evaluation is important as tattoo reactions may be associated with skin infections and malignancies. Legalization is needed for this practice to prevent tattoo reactions. Histopathological evaluation is important as tattoo reactions may be associated with skin infections and malignancies. Keeping vaccine strains up to date is the key to controlling equine