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The Most Effective ADHD Medication For Adults The majority of medications used to treat ADHD are classified into two categories: stimulants and nonstimulants. The stimulants, like methylphenidate or amphetamines stimulate brain areas that regulate attention and behavior. Nonstimulants, such as atomoxetine (Strattera), guanfacine (Intuniv) and clonidine (Kapvay), work slower t