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Epigenetic regulation plays a vital role in managing fungal secondary metabolic process. Here, we report the pleiotropic results of the epigenetic regulator HdaA (histone deacetylase) on secondary metabolite manufacturing and the linked biosynthetic gene groups (BGCs) expression when you look at the plant endophytic fungus Penicillium chrysogenum Fes1701. Deletion of this hdaA gene in strain Fes1701 caused a significant modification of the additional metabolite profile utilizing the emergence of