https://degrasyninhibitor.com/....sex-dependent-dysreg
At premigratory stages, an additional role manifests where Hmga1 loss reduces cranial crest emigration through the dorsal neural tube independent of Pax7. Interestingly, that is rescued by stabilized ß-catenin, thus implicating Hmga1 as a canonical Wnt activator. Together, our outcomes show that Hmga1 functions in a bimodal manner during neural crest development to modify specification at the neural dish border, and subsequent emigration through the neural tube via
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