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We illustrate the application of the method to investigate effect heterogeneity in the effect of statins on low-density lipoprotein cholesterol. Magnesium sulfate has neuroprotective effects in preterm infants. Whether other antepartum treatments interfere with the neuroprotective actions is not well known. This study aims to explore the impacts of antenatal administration of Magnesium sulfate or beta-2 adrenergic agonists as tocolytic agents on the developing brain in premature infants. This is a retrospective cohort study in four te