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The serum levels of TG and TC were significantly elevated in the tumor-bearing group compared with in the control group (P less then 0.01). Additionally, RT-qPCR analysis demonstrated that the expression levels of SENP7 were downregulated, while the expression levels of MARF1 and AANAT were upregulated in the ovaries of the tumor-bearing group compared with in the control group (P less then 0.01). In conclusion, the findings of the present study suggested that cancer may affect the reproductive system of mice and decrease the quality of ooc