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The partially cross-sectional nature of the data restricts the possibility of drawing causality with regards to associations between SES and substance use. Targeting substance use, particularly tobacco, can especially reduce depression risk in individuals of low SES. Targeting substance use, particularly tobacco, can especially reduce depression risk in individuals of low SES. Unipolar depression is a common and debilitating disorder. Immunological explanatory approaches have become increasingly important in recent years and can be studi