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01, P less then 0.05) in B(a)P-induced group compared with the control group. P-ERK and P-JNK expression decreased (P less then 0.01), while P-p38, Cyclin D1 and CDK4 expression increased (P less then 0.05, P less then 0.05, P less then 0.01) in B(a)P-induced group compared with the silica-induced group. CONCLUSION MAPK and cyclin D1/CDK4 activation expressed differently in human embryo lung fibroblasts malignant transformation induced by silica and benzopyrene.OBJECTIVE to identify evidence in the literature about financial toxicity i