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From the ROC curve that enables ≥95% of irregular free thyroxine leads to be recognized, the thyrotropin values obtained were ≥4.58 mIU/L and ≤0.94 mIU/L. These thyrotropin cut-off values would induce a saving of 22.7percent of yearly free thyroxine measurements without unfavorable medical effects. DISCUSSION Setting optimized thyrotropin cutoffs for reflex screening of no-cost thyroxine would reduce steadily the dependence on this test. Clinical l
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