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Results individual platelets sensitized with anti-platelet antibodies had been rapidly opsonized with iC3b upon incubation in individual sera. This opsonization could be totally blocked with a classical pathway complement inhibitor, PA-dPEG24. Complement activation decreased platelet viability, that has been additionally reversible with complement inhibitor PA-dPEG24. A new rat style of platelet refractoriness was created that shown some platelet removal from the system was co