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Leukemia constitutes just 3% of all malignancies but because of its high incidence and mortality in children and persons below 40 years of age, it is considered one of the devastating malignant conditions. This study was undertaken to evaluate the anticancer effects of Friedelin triterpenoid against the human AML-196leukemia cells. CCK-8 assay was used to determine cell viability. DAPI staining was used for the assessment of apoptosis. Annexin V/propidium iodide (PI) analysis was employed for the detection of percentage of apoptosis. Trans