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In summary, AQP5 regulated the proliferation and differentiation of epidermal stem cells in skin aging, and it may play an important role in the balance of proliferation and differentiation. However, further studies are needed to determine the mechanism by which AQP5 regulates the proliferation and differentiation of epidermal skin cells in aging. to describe the structure used in the School Health Program and analyze the association between its material resources and the actions carried out. cross-sectional, quantitative, analytical, an