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Finding the Best Medication For ADHD The most common medication prescribed for ADHD is stimulants. Amphetamines and methylphenidates are among the most frequently prescribed stimulants. Short-acting stimulants begin to work within less than an hour and should be taken multiple times throughout the day. Long-acting stimulations last up to 16 hour and are taken once a day. Your doctor might prescribe antidepressants and other types of drugs "off-label" to treat ADHD symptoms. These are drugs approve