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Taken together, these findings may have clinical significance in preventing the development of RION. Blood flow-restricted exercise (BFRE) appears to hold considerable potential in spinal cord injury (SCI) rehabilitation, due to its ability to induce beneficial functional changes and morphological alterations from low-intensity, low-load exercise. However, it remains unclear if this training approach is feasible and safe in individuals with autonomic dysreflexia (AD). A 23-year-old male with traumatic, cervical (C6), motor-complete (AIS