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ADHD Treatment For Adults - Stimulant Medication Stimulant drugs like methylphenidate and dextroamphetamine are generally considered first-line therapy for adult ADHD. These drugs boost and balance neurotransmitters in the brain. Antidepressants and nonstimulant medications like atomoxetine can be prescribed if stimulants are not suitable for the patient due to health problems or adverse effects. These medications have a slower effect than stimulants, and they reduce the impulsivity and lack o