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34, 95% CI 1.86-2.95), but this difference was attenuated to non-significant levels (AHR 1.29, 95% CI 0.92-1.81) following adjustments with adverse maternal characteristics and OHC. OHC mediated 61% (95% CI 0.41-0.94) of the association between prenatal substance exposure and youth's mood and neurotic disorders. Register data likely include more severe cases of disorders, and as an observational study, causality cannot be assessed. Mood and neurotic disorders are more common following prenatal exposure to substances and interlinked with