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Raloxifene and bazedoxifene inhibit IL-6 signaling at therapeutic amounts, recommending they have the possibility to avoid the cytokine storm, ARDS and death in severe COVID-19 patients, as is becoming shown with humanized antibodies blocking IL-6 signaling. In inclusion, raloxifene and bazedoxifene are selective estrogen receptor modulators with powerful antiviral activity. The ivermectin docking we identified may restrict the attachment associated with spike into the human mobi