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Most Effective ADHD Medication For Adults Most adults find that medication helps them focus, feel calmer and improve their relationships. Other treatment options like psychotherapy can also be aided by medications. Adults suffering from ADHD are most likely to benefit from stimulants. They include amphetamine and methylphenidate compounds. Adults can take long-acting drugs that are slow-acting but last for 3 to 6 hours or short-acting medication frequently throughout the day. Stimulants Stim