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Knowledge of occupational disparities may aid chronic disease prevention by identifying populations for targeted interventions. To describe caregiving work outcomes and related indirect (ie, productivity) and direct (ie, caregiving hours and expenses) costs. A national, population-based survey to identify employed caregivers assisting a person with treatment-resistant depression (TRD) and a comparison group of employed caregivers assisting others (No TRD). Screening identified 169 TRD caregivers and 1070 No TRD caregivers providing 23.