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This article has an associated 'The people behind the papers' interview. A number of fibro-osseous and osteocartilaginous lesions, especially common in the small bones of hand and feet, pose a diagnostic challenge and have historically been thought to be reactive lesions. However, modern molecular techniques when supplementing clinical, radiographic, and histologic evaluation suggest they may, in fact, be neoplasms. To review the clinical presentation and histopathologic, molecular, and radiologic features of selective bone lesions, focusing most sp