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A patient with progressive disseminated histoplasmosis was noted to have an increase in urine Histoplasma antigen level during monitoring of her disease. The patient revealed she had inadequately hydrated, and her urine volume was low and subjectively concentrated. Following hydration, urine antigen was retested and became undetectable. © 2019 The Author(s). Published by Informa UK Limited, trading as Taylor Francis Group on behalf of Greater Baltimore Medical Center.Background In the USA cancer is the second leading c