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0 mg/dl). W258X was only the risk in males with SUA of ≤ 3.0 mg/dl. Our study accurately reveals the prevalence of RHUC and provides genetic evidence for its definition (SUA ≤ 2.0 mg/dl). We also show that individuals with SUA of ≤ 3.0 mg/dl, especially males, are prone to RHUC. Our findings will help to promote a better epidemiological understanding of RHUC as well as more accurate diagnosis, especially in males with mild hypouricemia. Our study accurately reveals the prevalence of RHUC and provides genetic evidence for its definition
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