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Nevertheless, this has become clear that their particular biogenesis takes place in the endoplasmic reticulum (ER) and it is a lipid driven process. LD formation is intiatied because of the demixing of natural lipids from membrane phospholipids, resulting in the synthesis of a neutral lipid "lens" like construction amongst the leaflets of this ER bilayer. Since this lens develops, it buds out of the membrane layer to the cytosol to offer increase t