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To examine syphilis serology after treatment in people living with HIV. No unanimous guidelines exist in the era of increasing coinfection. Retrospective review using a tertiary care clinic in Toronto from 2000 to 2017. The 2015 Centers for Diseases Control and Prevention syphilis guidelines were used to define an adequate serologic response. Cumulative distribution estimates and proportional hazards models accounting for interval censoring estimated the time to serologic response and seroreversion. Multistate models were used to invest