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Herein, a sensitive, robust, and rapid liquid chromatographic coupled tandem size spectrometric method was created and validated when it comes to dedication of citalopram (CIT) and sertraline (SER) in rat plasma after dental administration. The analytes of great interest and inner standard (duloxetine (DUL)) were obtained from 100 μL of plasma with solid-phase removal on an Oasis HLB cartridge accompanied by the split with gradient elution with water containing 0.1% formic acid and acetonitrile
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