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This study aimed to evaluate the effect of low- and high-pressure pneumoperitoneum pressures applied during robotic-assisted laparoscopic prostatectomy (RALP) using Near-infrared Spectroscopy (NIRS) on regional cerebral oxygenation saturation (rSO2). The prospective, comparative, and observational study included patients aged 18-80 years, with the American Society of Anesthesiologists (ASA) physical status I-II, who would undergo elective RALP. The patients were divided into two groups (12 mmHg of pneumoperitoneum pressure group; n=22,