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mainly associated with severe metabolic derangement. Registration URL https//www.clinicaltrials.gov; Unique identifier NCT04358029. Prior studies investigating associations of rheumatoid factor (RF) and anti-citrullinated protein antibody (ACPA) seropositivity with risk for rheumatoid arthritis (RA)-associated interstitial lung disease (ILD) have mostly utilized cross-sectional or case-control designs. To determine whether combined autoantibody seropositivity and higher individual autoantibody concentrations were associated with increased