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8% (95% CI0.9-22.6, p=0.033); neopterin, 11.2% (95% CI3.2-19.2, p=0.007); D-dimer 9.6% (95% CI 3.1-15.9, p=0.004) respectively. The associations remained significant when analysis i)was stratified by N(t)RTI vs RAL; ii) included only patients with viral suppression at week forty-eight. A significant gradient in lean mass gain was seen across quartiles of IL-6, TNF, neopterin, hsCRP, D-dimer, and sCD14. Inflammatory biomarkers provide important mechanistic insights into the pathogenesis of limb fat and lean mass changes independently of