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However, care should be taken in terms of which enzyme is used with which protocol, particularly when scaling up.Objective Determine the effectiveness of spinal cord stimulation (SCS) for the treatment of axial low back pain (LBP) with or without leg pain. Design Systematic review. Subjects Persons aged ≥18 with axial LBP with or without accompanying leg pain. Intervention Traditional low-frequency, burst, or high-frequency SCS. Comparison Sham, active standard of care treatment, or none. Outcomes The primary outcome was ≥50% pain impro