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ADHD Medications - Stimulant Or Non Stimulant? For many, stimulant medications are the first choice for treating ADHD. However, for some individuals, they can cause adverse effects or don't help. Doctors sometimes prescribe non-stimulant ADHD medications instead, or in combination with stimulants. These include medications to treat high blood pressure, such as clonidine or Guanfacine (Tenex). These include other medicines that promote awakening. Benefits The first prescription medicati